Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045927 | 1.00 | HSD11B1 (0.49) | HSD11B1DPP8DPP7JAK2JAK1 | |
| SCHEMBL26966078 | 1.00 | HSD11B1 (0.49) | HSD11B1DPP8DPP7JAK2JAK1 | |
| SCHEMBL30722334 | 1.00 | HSD11B1 (0.49) | HSD11B1DPP8DPP7JAK2JAK1 | |
| SCHEMBL26966058 | 0.89 | HSD11B1 (0.39) | HSD11B1DPP8DPP7JAK2JAK1 | |
| SCHEMBL30722353 | 0.89 | HSD11B1 (0.39) | HSD11B1DPP8DPP7JAK2JAK1 | |
| SCHEMBL27273561 | 0.84 | HSD11B1 (0.48) | HSD11B1DPP8DPP7JAK2JAK1 | |
| SCHEMBL6980390 | 0.83 | CTSD (0.53) | HSD11B1JAK2JAK1HDAC3HDAC1 | |
| SCHEMBL895157 | 0.82 | HSD11B1 (0.53) | HSD11B1JAK2JAK1HDAC3HDAC1 | |
| SCHEMBL26966073 | 0.81 | CYP1A2 (0.37) | HSD11B1CYP2D6 | |
| SCHEMBL10207431 | 0.80 | HSD11B1 (0.56) | HSD11B1JAK2JAK1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4462943-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0052991-A1 | Carboxyalkyl amino acid derivatives of various substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-02 | — | — | EP | disclosed |