Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alclometasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | PGR | P06401 | 8/20 | 1.00 |
| ▸ | USP2 | O75604 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | CNR1 | P21554 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alclometasone Dipropionate SCHEMBL13985345 | 1.00 | PGR (1.00) | PGRUSP2NR3C1CYP3A4HIF1A | |
| Alclometasone Dipropionate SCHEMBL6833 | 1.00 | PGR (1.00) | PGRUSP2NR3C1CYP3A4HIF1A | |
| Alclometasone Dipropionate SCHEMBL29459697 | 1.00 | PGR (1.00) | PGRUSP2NR3C1CYP3A4HIF1A | |
| Alclometasone Dipropionate SCHEMBL13423590 | 1.00 | PGR (1.00) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL13653198 | 0.92 | PGR (0.86) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL36537 | 0.92 | NR3C1 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL11584194 | 0.92 | USP2 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL11584722 | 0.92 | NR3C1 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL14339625 | 0.92 | NR3C1 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL11584724 | 0.92 | NR3C1 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | claimed |
| US-4076708-A | Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby | SCHERING CORPORATION (US) | 1978-02-28 | — | — | US | claimed |
| US-4440690-A | Process for the synthesis of 6-bromo-17,21-dihydroxy 3,11,20-trioxo-1,4-pregnadienes 17,21-diesters | SCHERING CORPORATION (US) | 1984-04-03 | — | — | US | disclosed |
| US-4427591-A | TOPICAL ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1984-01-24 | — | — | US | disclosed |
| US-4336200-A | 17α-Acyloxy-5β-corticoids | THE UPJOHN COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4318853-A | ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | disclosed |
| US-4076708-A | Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby | SCHERING CORPORATION (US) | 1978-02-28 | — | — | US | disclosed |