Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alclometasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | PGR | P06401 | 8/20 | 1.00 |
| ▸ | USP2 | O75604 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | CNR1 | P21554 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alclometasone Dipropionate SCHEMBL13985345 | 1.00 | PGR (1.00) | PGRUSP2NR3C1CYP3A4HIF1A | |
| Alclometasone Dipropionate SCHEMBL11047317 | 1.00 | PGR (1.00) | PGRUSP2NR3C1CYP3A4HIF1A | |
| Alclometasone Dipropionate SCHEMBL29459697 | 1.00 | PGR (1.00) | PGRUSP2NR3C1CYP3A4HIF1A | |
| Alclometasone Dipropionate SCHEMBL13423590 | 1.00 | PGR (1.00) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL13653198 | 0.92 | PGR (0.86) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL36537 | 0.92 | NR3C1 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL11584194 | 0.92 | USP2 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL11584722 | 0.92 | NR3C1 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL14339625 | 0.92 | NR3C1 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A | |
| SCHEMBL11584724 | 0.92 | NR3C1 (0.85) | PGRUSP2NR3C1CYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8895 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4724040-A1 | TREATMENT OF PSORIASIS | TRADOVA (PTY) LTD (ZA) | 2026-04-15 | — | — | EP | claimed |
| EP-3820479-B1 | METHODS TO REDUCE COMPLICATIONS OF INTRA-ARTICULAR STEROID | TAIWAN LIPOSOME CO LTD (TW) | 2026-03-11 | — | — | EP | claimed |
| EP-3717017-B1 | COVALENT ANESTHETIC-POLYMER CONJUGATES FOR PROLONGED LOCAL ANESTHESIA | CHILDRENS MEDICAL CT CORP (US) | 2026-02-25 | — | — | EP | claimed |
| US-20260034056-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING OCULAR DISEASES OR DISORDERS | ALCON INC (CH) | 2026-02-05 | — | — | US | claimed |
| EP-4301343-B1 | PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME | TLC BIOPHARMACEUTICALS INC (US) | 2025-11-19 | — | — | EP | claimed |
| US-20250312274-A1 | A PHARMACEUTICAL FORMULATION FOR PRESSURISED METERED DOSE INHALER | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-10-09 | — | — | US | claimed |
| US-20250302742-A1 | A PHARMACEUTICAL FORMULATION FOR PRESSURISED METERED DOSE INHALER | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-10-02 | — | — | US | claimed |
| US-20250288585-A1 | SYNERGISTIC COMPOSITIONS FOR ENHANCED HAIR GROWTH AND METHODS FOR TREATING HAIR LOSS | THE JOHNS HOPKINS UNIVERSITY | 2025-09-18 | — | — | US | claimed |
| WO-2025096949-A1 | LIPOSOMAL COMPOSITION OF INTRA-ARTICULAR CORTICOSTEROID FOR PAIN CONTROL | TAIWAN LIPOSOME COMPANY, LTD. (CN) | 2025-05-08 | — | — | WO | claimed |
| EP-0579760-A1 | METHOD OF TREATMENT USING STEROID MOUTHWASH | Eisen, Drore (US) | 1994-01-26 | — | — | EP | claimed |
| WO-1992018133-A1 | METHOD OF TREATMENT USING STEROID MOUTHWASH | EISEN DRORE (US) | 1992-10-29 | — | — | WO | claimed |
| EP-0362270-B1 | STEROID LOTION | SCHERING CORPORATION (US) | 1992-07-01 | — | — | EP | claimed |
| US-5061700-A | SOLVENTS FOR CORTICOSTEROIDS | Dow, Gordon Jay (US) | 1991-10-29 | — | — | US | claimed |
| WO-1991007169-A1 | GLYCERYL ACETATE OINTMENT VEHICLES | DOW GORDON JAY (US) | 1991-05-30 | — | — | WO | claimed |
| EP-0362270-A1 | STEROID LOTION. | SCHERING CORP (US) | 1990-04-11 | — | — | EP | claimed |
| WO-1988009174-A1 | STEROID LOTION | SCHERING CORPORATION (US) | 1988-12-01 | — | — | WO | claimed |
| EP-0292893-A1 | Steroid lotion | SCHERING CORPORATION (US) | 1988-11-30 | — | — | EP | claimed |
| US-4775529-A | ANTIINFLAMMATORY, VASOCONSTRICTION; PROPYLENE GLYCOL; ISOPROPANOL AND THICKENER; SKIN DISORDERS | SCHERING CORPORATION (US) | 1988-10-04 | — | — | US | claimed |
| EP-0097374-A2 | Corticosteroid topical preparation | SHIONOGI & CO., LTD. (JP) | 1984-01-04 | — | — | EP | claimed |