Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11046488 | 0.85 | POLB (0.53) | POLBKMT2AALDH1A1MEN1CYP3A4 | |
| SCHEMBL11046813 | 0.83 | POLB (0.56) | POLBKMT2AALDH1A1MEN1CYP3A4 | |
| SCHEMBL11047671 | 0.79 | F10 (0.48) | POLBKMT2AALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL3411721 | 0.77 | OPRM1 (0.66) | POLBKMT2AALDH1A1MEN1F10 | |
| SCHEMBL613806 | 0.75 | POLB (0.51) | POLBKMT2AALDH1A1MEN1CYP3A4 | |
| SCHEMBL12170296 | 0.74 | ALDH1A1 (0.52) | POLBKMT2AALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL11988867 | 0.71 | POLB (0.62) | POLBKMT2AALDH1A1MEN1CYP3A4 | |
| SCHEMBL16802088 | 0.71 | HSD11B1 (0.56) | KMT2AMEN1CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL301027 | 0.71 | KMT2A (0.64) | POLBKMT2AALDH1A1MEN1CYP3A4 | |
| SCHEMBL31525688 | 0.71 | ALDH1A1 (0.60) | POLBKMT2AALDH1A1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035902-B1 | 1-(4-ARYL-CYCLOHEXYL)PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-10-31 | — | — | EP | disclosed |
| US-4329353-A | ANTIEMETIC AND NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-05-11 | — | — | US | disclosed |
| EP-0035902-A1 | 1-(4-Aryl-cyclohexyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-09-16 | — | — | EP | disclosed |