Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | LPL | P06858 | 2/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108740 | 0.79 | KDM4E (0.37) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL4822833 | 0.73 | TRPA1 (0.57) | LPLLIPGAURKATRPA1 | |
| SCHEMBL15504185 | 0.70 | CYP1A2 (0.46) | CYP1A2LPLLIPGPRMT5WDR77 | |
| SCHEMBL29414051 | 0.68 | ATM (0.44) | KDM4EGAACYP3A4ALDH1A1LPL | |
| SCHEMBL18935357 | 0.68 | GPR3 (0.44) | KDM4EGAACYP1A2ALDH1A1HPGD | |
| SCHEMBL2111365 | 0.68 | ATM (0.44) | KDM4EGAACYP3A4ALDH1A1LPL | |
| SCHEMBL189955 | 0.68 | IDO1 (0.50) | IDO1LPLLIPG | |
| SCHEMBL29376674 | 0.68 | IDO1 (0.50) | IDO1LPLLIPG | |
| SCHEMBL2018549 | 0.68 | LPL (0.50) | LPLLIPG | |
| SCHEMBL30379604 | 0.67 | PRMT5 (0.42) | CYP1A2IDO1LPLLIPGPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483523-B | Pyrazolopyrimidine derivative epidermal growth factor inhibitor and preparation method and application thereof | 药雅科技(上海)有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-110452243-B | Pyrrolopyrimidine derivative epidermal growth factor inhibitor and preparation method and application thereof | 药雅科技(上海)有限公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-105461695-B | Pyrimidine or pyrrolotriazine derivatives and its production and use | 齐鲁制药有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-103664898-A | Organometallic compound and organic light-emitting device including the same | SAMSUNG DISPLAY CO LTD | 2014-03-26 | — | — | CN | disclosed |
| US-8153639-B2 | kinase inhibitor; immunotherapy; viricides; function or behavior associated with PI3 kinase such as cancer, immune, cardiovascular, nervous system, metabolism/endocrine and neurological diseases, viral infection, inflammation; 3-(4-Pyridin-4-yl-thieno[3,2-d]pyrimidin-2-yl)-phenol | F. HOFFMAN-LA ROCHE AG (CH) | 2012-04-10 | — | — | US | disclosed |
| US-20090209559-A1 | PHARMACEUTICAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209559-A1 | PHARMACEUTICAL COMPOUNDS | PIK3CA, JAK2, PIK3CD | KDM4E 3774/4885GAA 1425/4885PDPK1 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.