Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5250338 | 1.00 | SIGMAR1 (0.44) | SIGMAR1CYP19A1SLC18A3OPRM1OPRD1 | |
| SCHEMBL8777947 | 0.98 | SIGMAR1 (0.42) | SIGMAR1CYP19A1SLC18A3OPRM1OPRD1 | |
| SCHEMBL9432698 | 0.94 | SLC18A3 (0.46) | SIGMAR1CYP19A1SLC18A3OPRM1OPRD1 | |
| SCHEMBL9433185 | 0.89 | CYP19A1 (0.44) | SIGMAR1CYP19A1SLC18A3CCR3 | |
| SCHEMBL11042566 | 0.87 | CTSS (0.47) | OPRM1OPRD1OPRK1 | |
| SCHEMBL18435050 | 0.82 | SIGMAR1 (0.61) | SIGMAR1CYP19A1SLC18A3OPRM1OPRD1 | |
| SCHEMBL8116499 | 0.81 | CYP19A1 (0.47) | SIGMAR1CYP19A1SLC18A3CCR3 | |
| SCHEMBL8111557 | 0.81 | CYP19A1 (0.47) | SIGMAR1CYP19A1SLC18A3CCR3 | |
| SCHEMBL7392307 | 0.80 | SIGMAR1 (0.64) | SIGMAR1SLC18A3 | |
| SCHEMBL5087578 | 0.80 | SIGMAR1 (0.64) | SIGMAR1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |