SCHEMBL11049679

SCHEMBL11049679

CCCCCNC(=O)NS(=O)(=O)c1ccccc1

nearest known ligand 0.76

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.69
ALDH1A1 P00352 2/20 0.69
LMNA P02545 2/20 0.69
TSHR P16473 2/20 0.69
ALB P02768 1/20 0.69
TDP1 Q9NUW8 1/20 0.69
FBP1 P09467 12/20 0.67
EPHX2 P34913 2/20 0.66
GHSR Q92847 1/20 0.61
CYP3A4 P08684 1/20 0.58
THRB P10828 1/20 0.58
NFKB1 P19838 1/20 0.58
HTR2A P28223 1/20 0.58
CYP2C19 P33261 1/20 0.58
ADRA1A P35348 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
NPSR1 Q6W5P4 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28534045 0.98 EPHX2 (0.68) CYP2C9ALDH1A1LMNATSHRALB
SCHEMBL19271872 0.98 EPHX2 (0.68) CYP2C9ALDH1A1LMNATSHRALB
SCHEMBL184964 0.95 CYP2C9 (0.76) CYP2C9ALDH1A1LMNATSHRALB
Methyl Alcohol SCHEMBL28260710 0.94 CYP2C9 (0.74) CYP2C9ALDH1A1LMNATSHRALB
SCHEMBL5931108 0.91 FBP1 (0.70) CYP2C9ALDH1A1LMNATSHRALB
SCHEMBL2290886 0.89 ALDH1A1 (0.72) CYP2C9ALDH1A1LMNATSHRALB
SCHEMBL6464356 0.87 CYP2C9 (0.72) CYP2C9ALDH1A1LMNATSHRALB
SCHEMBL8672470 0.87 ALDH1A1 (0.91) CYP2C9ALDH1A1LMNATSHRALB
SCHEMBL23876511 0.85 ALDH1A1 (0.89) CYP2C9ALDH1A1LMNATSHRALB
SCHEMBL5931121 0.85 ALDH1A1 (0.89) CYP2C9ALDH1A1LMNATSHRALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4542139-A HYPOGLYCEMIC AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1985-09-17 US disclosed
US-4379785-A Heterocyclic substituted sulfonyl ureas, and their use HOECHST AKTIENGESELLSCHAFT (DE) 1983-04-12 US disclosed
US-4325963-A ANTIDIABETIC AGENT HOECHST AKTIENGESELLSCHAFT (DE) 1982-04-20 US disclosed
US-4025519-A HYPOGLYCEMIC AGENTS HOECHST AKTIENGESELLSCHAFT (DT) 1977-05-24 US disclosed
US-3939269-A Benzenesulfon YL-semicarbazides for lowering blood sugar levels HOECHST AKTIENGESELLSCHAFT (DT) 1976-02-17 US disclosed
US-3932658-A Composition and method for lower blood sugar containing N-[4-(β-<2-methoxy-5-chloro-benzamido>-ethyl)-benzenesulfonyl]-N'-cyclopentyl-urea HOECHST AKTIENGESELLSCHAFT (DT) 1976-01-13 US disclosed