SCHEMBL11052001

SCHEMBL11052001

Oc1ccc(C(F)(c2ccc(O)cc2)C(F)(F)C(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 11/20 0.48
ESR2 Q92731 11/20 0.48
KIF11 P52732 1/20 0.46
CYP3A4 P08684 3/20 0.41
LMNA P02545 2/20 0.41
TYR P14679 2/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 2/20 0.41
AR P10275 1/20 0.41
TSHR P16473 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
HTR6 P50406 1/20 0.41
ESRRG P62508 1/20 0.41
SLC6A3 Q01959 1/20 0.41
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
CA12 O43570 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL320071 0.82 ESR1 (0.48) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL27620452 0.76 ESR1 (0.52) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL6130606 0.73 ESR1 (0.48) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL3685809 0.73 ESR1 (0.54) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL1719753 0.73 ESR1 (0.54) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL306439 0.71 ESR1 (0.58) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL28512548 0.71 ESR1 (0.52) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL11124938 0.70 ESR1 (0.54) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL3679251 0.70 ESR1 (0.56) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL27878898 0.70 ESR1 (0.50) ESR1ESR2KIF11CYP3A4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4467121-A Fluorinated diphenols and method for their preparation GENERAL ELECTRIC COMPANY (US) 1984-08-21 US disclosed
EP-0067852-A4 FLAME RETARDANT AROMATIC POLYESTER-CARBONATE COPOLYMER COMPOSITIONS. GEN ELECTRIC (US) 1983-05-16 EP disclosed
US-4379910-A Flame retardant aromatic polycarbonate compositions made from fluorinated diphenols GENERAL ELECTRIC CO. (US) 1983-04-12 US disclosed
EP-0067853-A4 FLAME RETARDANT AROMATIC POLYCARBONATES MADE FROM FLUORINATED DIPHENOLS. GEN ELECTRIC (US) 1983-04-06 EP disclosed
EP-0067852-A1 FLAME RETARDANT AROMATIC POLYESTER-CARBONATE COPOLYMER COMPOSITIONS. GEN ELECTRIC (US) 1982-12-29 EP disclosed
EP-0067853-A1 FLAME RETARDANT AROMATIC POLYCARBONATES MADE FROM FLUORINATED DIPHENOLS. GEN ELECTRIC (US) 1982-12-29 EP disclosed
US-4365098-A Fluorinated diphenols and method for their preparation GENERAL ELECTRIC COMPANY (US) 1982-12-21 US disclosed
US-4349658-A Flame retardant aromatic polyester-carbonate copolymer compositions GENERAL ELECTRIC COMPANY (US) 1982-09-14 US disclosed
WO-1982002402-A1 FLAME RETARDANT AROMATIC POLYCARBONATE COMPOSITIONS MADE FROM FLUORINATED DIPHENOLS GEN ELECTRIC (US) 1982-07-22 WO disclosed
WO-1982002390-A1 FLAME RETARDANT AROMATIC POLYESTER-CARBONATE COPOLYMER COMPOSITIONS GEN ELECTRIC (US) 1982-07-22 WO disclosed