Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 2/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
| ▸ | CPB1 | P15086 | 1/20 | 0.30 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11046359 | 0.84 | CPB1 (0.39) | NOTUMPDE3BPDE3ACPB1CPB2 | |
| SCHEMBL11050130 | 0.81 | PDE3B (0.41) | NOTUMPDE3BPDE3ACOMTCPB1 | |
| SCHEMBL11047534 | 0.79 | COMT (0.46) | NOTUMPDE3BPDE3ACOMTCPB1 | |
| SCHEMBL11350776 | 0.76 | CPB1 (0.38) | NOTUMPDE3BPDE3ACOMTCPB1 | |
| SCHEMBL11051360 | 0.74 | NOTUM (0.36) | NOTUMPDE3BPDE3ACPB1CPB2 | |
| SCHEMBL4432563 | 0.74 | NOTUM (0.51) | NOTUMPDE3BPDE3ACOMTCPB1 | |
| SCHEMBL4427890 | 0.73 | NOTUM (0.55) | NOTUMPDE3BPDE3ACPB2KDM4E | |
| SCHEMBL11047728 | 0.72 | PDE3B (0.40) | NOTUMPDE3BPDE3ACPB1CPB2 | |
| SCHEMBL11046403 | 0.71 | CPB1 (0.54) | NOTUMPDE3BPDE3ACPB1CPB2 | |
| SCHEMBL4429999 | 0.70 | RXRA (0.41) | NOTUMPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443466-A | DIURETICS, SEDATIVES, ANALGESICS | Farmos-Yhtyma OY (Farmos Group Ltd.) (FI) | 1984-04-17 | — | — | US | claimed |
| EP-0024829-B1 | 4-BENZYL- AND 4-BENZOYLIMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | Farmos-Yhtyma Oy (FI) | 1984-04-25 | — | — | EP | disclosed |
| US-4443466-A | DIURETICS, SEDATIVES, ANALGESICS | Farmos-Yhtyma OY (Farmos Group Ltd.) (FI) | 1984-04-17 | — | — | US | disclosed |
| EP-0024829-A1 | 4-Benzyl- and 4-benzoylimidazole derivatives, processes for their preparation and pharmaceutical compositions comprising the same | Farmos-Yhtyma Oy (FI) | 1981-03-11 | — | — | EP | disclosed |