Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11052077 | 0.89 | MEN1 (0.74) | POLBMEN1KMT2AMAPK1CYP1A2 | |
| SCHEMBL11265410 | 0.87 | KMT2A (0.56) | POLBMEN1KMT2AMAPK1RAB9A | |
| SCHEMBL11052110 | 0.86 | MEN1 (0.55) | POLBMEN1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL13900226 | 0.84 | MEN1 (0.76) | POLBMEN1KMT2AMAPK1CYP1A2 | |
| SCHEMBL11053827 | 0.84 | MAPK1 (0.54) | POLBMEN1KMT2AMAPK1PDK1 | |
| SCHEMBL11049769 | 0.84 | RAB9A (0.54) | POLBMEN1KMT2AMAPK1PDK1 | |
| SCHEMBL11053981 | 0.83 | PDK1 (0.50) | POLBMEN1KMT2AMAPK1PDK1 | |
| SCHEMBL11052114 | 0.83 | PDK1 (0.50) | POLBMEN1KMT2AMAPK1CYP1A2 | |
| SCHEMBL11051039 | 0.82 | HTT (0.49) | POLBMEN1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL11052904 | 0.82 | HTT (0.47) | POLBMEN1KMT2AMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |