Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057187 | 0.86 | KCNMA1 (0.50) | RAB9AMAPK1MEN1KMT2ANPC1 | |
| SCHEMBL11055535 | 0.85 | APP (0.54) | RAB9AMAPK1PKMMEN1KMT2A | |
| SCHEMBL11053343 | 0.83 | MEN1 (0.60) | ABCB1ABCC1RAB9AMAPK1MEN1 | |
| SCHEMBL11052503 | 0.83 | KCNMA1 (0.53) | RAB9AMAPK1PKMMEN1KMT2A | |
| SCHEMBL11050905 | 0.83 | NPC1 (0.51) | KDM4ERAB9AMAPK1MEN1KMT2A | |
| SCHEMBL11579191 | 0.82 | MAPK1 (0.50) | KDM4EABCB1ABCC1RAB9AMAPK1 | |
| SCHEMBL11055583 | 0.82 | MAPT (0.47) | RAB9AMAPK1MEN1KMT2ANPC1 | |
| SCHEMBL11579742 | 0.82 | PDK1 (0.53) | RAB9AMAPK1MEN1KMT2ANPC1 | |
| SCHEMBL11052550 | 0.82 | GAA (0.51) | KDM4ERAB9APKMMEN1KMT2A | |
| SCHEMBL11053662 | 0.81 | NPC1 (0.49) | KDM4ERAB9AMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |