Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057187 | 0.87 | KCNMA1 (0.50) | KCNMA1MAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL11049781 | 0.85 | KIF11 (0.46) | MEN1KMT2AHTT | |
| SCHEMBL11813657 | 0.84 | KCNMA1 (0.53) | KCNMA1MAPTALDH1A1MAPK1PKM | |
| SCHEMBL11580645 | 0.84 | KCNMA1 (0.56) | KCNMA1MAPTALDH1A1MAPK1PKM | |
| SCHEMBL11255956 | 0.84 | MEN1 (0.42) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL11055535 | 0.83 | APP (0.54) | KCNMA1MAPTALDH1A1MAPK1PKM | |
| SCHEMBL11052878 | 0.83 | KDM4E (0.47) | MAPTALDH1A1MAPK1PKMMEN1 | |
| SCHEMBL11050004 | 0.82 | CA12 (0.47) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL11053855 | 0.82 | MAPT (0.40) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL11250280 | 0.82 | LMNA (0.41) | MAPTPKMMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |