Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11051039 | 0.89 | HTT (0.49) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11257947 | 0.88 | MAPK1 (0.43) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11050083 | 0.86 | MAPK1 (0.55) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11052110 | 0.86 | MEN1 (0.55) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11054793 | 0.84 | NPC1 (0.44) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11578638 | 0.80 | KMT2A (0.40) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11052138 | 0.80 | KMT2A (0.40) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11056090 | 0.78 | NPC1 (0.39) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11056782 | 0.78 | MAPK1 (0.48) | MEN1KMT2AMAPK1RAB9ANPC1 | |
| SCHEMBL11049769 | 0.78 | RAB9A (0.54) | MEN1KMT2AMAPK1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |