Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11054793 | 0.92 | NPC1 (0.44) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL11050055 | 0.90 | KMT2A (0.45) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL11578638 | 0.86 | KMT2A (0.40) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL11578817 | 0.86 | SMN1; SMN2 (0.39) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL11056090 | 0.85 | NPC1 (0.39) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL11056782 | 0.85 | MAPK1 (0.48) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL11054677 | 0.85 | LMNA (0.40) | KMT2AMEN1LMNAHTTMAPK1 | |
| SCHEMBL11049616 | 0.84 | HTT (0.50) | KMT2AMEN1RAB9ALMNAHTT | |
| SCHEMBL11579645 | 0.83 | PTGS2 (0.41) | KMT2AMEN1LMNAHTTMAPK1 | |
| SCHEMBL11580574 | 0.82 | TBXA2R (0.39) | KMT2AMEN1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |