SCHEMBL11054879

SCHEMBL11054879

CNc1ncn(-c2c(C)cccc2Br)c(=O)n1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 4/20 0.38
WEE1 P30291 1/20 0.34
CHRNA7 P36544 8/20 0.33
EGFR P00533 1/20 0.32
FGFR1 P11362 1/20 0.32
SRC P12931 1/20 0.32
PAK1 Q13153 1/20 0.31
PAK2 Q13177 1/20 0.31
STK4 Q13043 1/20 0.31
STK3 Q13188 1/20 0.31
SIK2 Q9H0K1 1/20 0.31
STK26 Q9P289 1/20 0.31
STK24 Q9Y6E0 1/20 0.31
ELANE P08246 2/20 0.31
POLB P06746 1/20 0.31
PDE7A Q13946 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11054404 0.90 HCAR1 (0.46) HCAR1CHRNA7EGFRFGFR1SRC
Hydrochloric Acid SCHEMBL11052665 0.89 HCAR1 (0.44) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11056733 0.86 ALDH1A1 (0.37) HCAR1WEE1EGFRFGFR1ELANE
SCHEMBL11056462 0.86 HCAR1 (0.36) HCAR1WEE1CHRNA7FGFR1ELANE
SCHEMBL11058426 0.85 FGFR1 (0.41) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11057854 0.84 HCAR1 (0.41) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11054604 0.84 CHRNA7 (0.47) HCAR1WEE1CHRNA7EGFRFGFR1
SCHEMBL11050172 0.84 HCAR1 (0.38) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11059212 0.84 HCAR1 (0.38) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11055278 0.83 CDK1 (0.36) HCAR1WEE1CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4338441-A CYCLIZATION OF AMIDINOUREA OR AMIDINOTHIOUREA WITH ACTIVE METHYLIDENE COMPOUND WILLIAM H. RORER, INC. (US) 1982-07-06 US claimed
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4338441-A CYCLIZATION OF AMIDINOUREA OR AMIDINOTHIOUREA WITH ACTIVE METHYLIDENE COMPOUND WILLIAM H. RORER, INC. (US) 1982-07-06 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed
US-4203985-A Antidiarrheal triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4203983-A GASTROINTESTINAL DISORDERS WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4203984-A Antisecretory triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4198409-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed