SCHEMBL11054404

SCHEMBL11054404

CNc1ncn(-c2c(C)cccc2C)c(=O)n1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 5/20 0.46
CHRNA7 P36544 9/20 0.36
EGFR P00533 1/20 0.35
FGFR1 P11362 1/20 0.35
SRC P12931 1/20 0.35
ELANE P08246 2/20 0.34
POLB P06746 2/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11052665 0.98 HCAR1 (0.44) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11057854 0.93 HCAR1 (0.41) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11059212 0.90 HCAR1 (0.38) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11050172 0.90 HCAR1 (0.38) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11054879 0.90 HCAR1 (0.38) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL11054604 0.90 CHRNA7 (0.47) HCAR1CHRNA7EGFRFGFR1SRC
SCHEMBL10541727 0.88 HCAR1 (0.43) HCAR1CHRNA7POLBMEN1ALDH1A1
SCHEMBL11058341 0.88 APLNR (0.38) HCAR1FGFR1POLBMEN1ALDH1A1
SCHEMBL10541358 0.86 HCAR1 (0.44) HCAR1CHRNA7SRC
SCHEMBL11059402 0.86 KMT2A (0.39) HCAR1ELANEPOLBMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4338441-A CYCLIZATION OF AMIDINOUREA OR AMIDINOTHIOUREA WITH ACTIVE METHYLIDENE COMPOUND WILLIAM H. RORER, INC. (US) 1982-07-06 US claimed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US claimed
US-4203985-A Antidiarrheal triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US claimed
US-4198409-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-04-15 US claimed
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4338441-A CYCLIZATION OF AMIDINOUREA OR AMIDINOTHIOUREA WITH ACTIVE METHYLIDENE COMPOUND WILLIAM H. RORER, INC. (US) 1982-07-06 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed
US-4203985-A Antidiarrheal triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4203983-A GASTROINTESTINAL DISORDERS WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4203984-A Antisecretory triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4198409-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed