Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.32 |
| ▸ | CCR1 | P32246 | 2/20 | 0.31 |
| ▸ | CCR5 | P51681 | 2/20 | 0.31 |
| ▸ | CCR8 | P51685 | 2/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157930 | 0.79 | LMNA (0.61) | LMNACYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL21001801 | 0.79 | LMNA (0.61) | LMNACYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL710195 | 0.79 | LMNA (0.67) | LMNACYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL31143538 | 0.78 | LMNA (0.59) | LMNACYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL22045599 | 0.78 | PKM (0.46) | LMNACYP3A4KDM4EMAPTPKM | |
| Naphthalene SCHEMBL28746803 | 0.77 | LMNA (0.58) | LMNACYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL30917372 | 0.75 | LMNA (0.51) | LMNACYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL28493651 | 0.74 | LMNA (0.82) | LMNACYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL5804134 | 0.74 | LMNA (0.59) | LMNACYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL11499049 | 0.74 | LMNA (0.31) | LMNACYP3A4KDM4EMAPTCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4450108-A | ANTIDEPRESSANTS; NEUROLEPTIC AGENTS; PSYCHOLOGICAL DISORDERS | SANDOZ LTD. (CH) | 1984-05-22 | — | — | US | disclosed |
| US-4450108-A | ANTIDEPRESSANTS; NEUROLEPTIC AGENTS; PSYCHOLOGICAL DISORDERS | SANDOZ LTD. (CH) | 1984-05-22 | — | — | US | disclosed |
| US-4450108-A | ANTIDEPRESSANTS; NEUROLEPTIC AGENTS; PSYCHOLOGICAL DISORDERS | SANDOZ LTD. (CH) | 1984-05-22 | — | — | US | disclosed |
| EP-0031115-A1 | New pyrrolobenzotriazepines, their production and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1981-07-01 | — | — | EP | disclosed |