Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057555 | 0.83 | ALDH1A1 (0.44) | ADRB1ALDH1A1PLA2G1BATG4BLMNA | |
| SCHEMBL11055378 | 0.81 | ADRB1 (0.50) | ADRB1ALDH1A1HSD11B1LMNAHTT | |
| SCHEMBL11054884 | 0.81 | ALDH1A1 (0.52) | ADRB1ALDH1A1LMNAHTTHTR1A | |
| SCHEMBL11076915 | 0.79 | ADRB1 (0.53) | ADRB1KDM4EALDH1A1LMNAHTR1A | |
| SCHEMBL28396664 | 0.79 | ADRB1 (0.71) | ADRB1KDM4EALDH1A1PLA2G1BRAB9A | |
| SCHEMBL11055227 | 0.78 | MAPT (0.49) | KDM4EALDH1A1RAB9ALMNAHTT | |
| SCHEMBL11057859 | 0.78 | DRD2 (0.59) | ADRB1KDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL9846801 | 0.77 | TSHR (0.45) | ALDH1A1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL9846799 | 0.77 | TSHR (0.45) | ALDH1A1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL11060301 | 0.76 | PLD1 (0.47) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4425342-A | 1-(Substituted) piperazine-4-benzenesulfinamides, compositions and method of use | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-01-10 | — | — | US | claimed |
| US-4425342-A | 1-(Substituted) piperazine-4-benzenesulfinamides, compositions and method of use | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0017079-A1 | Benzenesulfinamides, a process for the preparation thereof and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-15 | — | — | EP | disclosed |