Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981241 | 0.77 | RAB9A (0.41) | KMT2ANPC1RAB9A | |
| SCHEMBL6037395 | 0.76 | KMT2A (0.47) | KMT2ANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL27702200 | 0.75 | KMT2A (0.40) | KMT2AMAOBMEN1 | |
| SCHEMBL11485375 | 0.75 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6432858 | 0.75 | KMT2A (0.46) | KMT2ANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL29938476 | 0.73 | KMT2A (0.37) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10825235 | 0.72 | CYP4F2 (0.38) | KMT2ANPC1RAB9AS1PR5 | |
| SCHEMBL29938710 | 0.71 | CYP26A1 (0.46) | ALDH1A1MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL7342304 | 0.71 | BTK (0.39) | ALDH1A1MAPK1HSD17B10KMT2AMEN1 | |
| SCHEMBL6201848 | 0.71 | S1PR5 (0.58) | PIK3CAKMT2AKDM4ES1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4466977-A | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics | THE UPJOHN COMPANY (US) | 1984-08-21 | — | — | US | disclosed |
| EP-0108602-A1 | N-(2-aminocycloalkyl)benzamide and benzeneacetamide derivatives | THE UPJOHN COMPANY (US) | 1984-05-16 | — | — | EP | disclosed |
| US-4360531-A | Substituted cycloalkanes | THE UPJOHN COMPANY (US) | 1982-11-23 | — | — | US | disclosed |