Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 4/20 | 0.53 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203161 | 0.89 | RAB9A (0.64) | S1PR5PIK3CATSHRHAO1KMT2A | |
| SCHEMBL3036843 | 0.86 | S1PR5 (0.57) | S1PR5PIK3CATSHRHAO1KDM4E | |
| SCHEMBL1515720 | 0.85 | MAPT (0.66) | TSHRKMOKDM4EHSD11B1 | |
| SCHEMBL1515710 | 0.85 | S1PR5 (0.59) | S1PR5PIK3CAKMOHAO1KMT2A | |
| SCHEMBL5207216 | 0.83 | LMNA (0.67) | S1PR5TSHRKMT2A | |
| SCHEMBL3037831 | 0.82 | S1PR5 (0.53) | S1PR5PIK3CATSHRHAO1KMT2A | |
| SCHEMBL5762281 | 0.80 | ALDH1A1 (0.44) | S1PR5PIK3CATSHRKMOKDM4E | |
| SCHEMBL9015106 | 0.79 | TSHR (0.61) | TSHRKMOHAO1KDM4EKMT2A | |
| SCHEMBL5005689 | 0.78 | GSK3B (0.59) | TSHRKMOHSD11B1 | |
| SCHEMBL29836035 | 0.78 | GSK3B (0.59) | TSHRKMOHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |