Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11133436 | 0.88 | ALOX12 (0.48) | ALOX12RECQLLMNAALDH1A1CYP1A2 | |
| SCHEMBL11269527 | 0.85 | ATM (0.42) | ALOX12RECQLLMNAALDH1A1CYP1A2 | |
| SCHEMBL11054397 | 0.85 | LMNA (0.51) | ALOX12RECQLLMNAALDH1A1CYP1A2 | |
| SCHEMBL11058243 | 0.82 | LMNA (0.49) | ALOX12RECQLLMNAALDH1A1CYP1A2 | |
| SCHEMBL10943897 | 0.81 | POLB (0.54) | ALOX12RECQLLMNAALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL11219171 | 0.80 | PKM (0.54) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11058402 | 0.78 | LMNA (0.53) | ALOX12RECQLLMNAALDH1A1CYP1A2 | |
| SCHEMBL11052356 | 0.78 | POLB (0.51) | ALOX12RECQLLMNAALDH1A1CYP1A2 | |
| SCHEMBL11054260 | 0.78 | POLB (0.55) | ALOX12RECQLLMNAALDH1A1CYP1A2 | |
| SCHEMBL11051530 | 0.77 | GAA (0.50) | ALOX12LMNAALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4418209-A | ANTIULCER, ANTIARRYTHMIC, ANTIDIARRHEAL, ANTISPASMODIC, ANTIPARASITIC, AND ANTISECRETORY AGENTS | WILLIAM H. RORER, INC. (US) | 1983-11-29 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |