Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | DNM2 | P50570 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050354 | 0.88 | KCNH3 (0.41) | KCNH3EGFRFGFR1DNM2ELANE | |
| SCHEMBL11352072 | 0.86 | DNM2 (0.40) | KCNH3EGFRFGFR1DNM2ELANE | |
| SCHEMBL11054993 | 0.86 | KCNH2 (0.38) | EGFRFGFR1 | |
| SCHEMBL11053577 | 0.84 | MKNK1 (0.47) | KCNH3 | |
| SCHEMBL11053096 | 0.84 | ELANE (0.43) | KCNH3EGFRFGFR1ELANEHRH4 | |
| SCHEMBL11059128 | 0.82 | KCNH2 (0.37) | EGFRFGFR1 | |
| SCHEMBL11056312 | 0.81 | LCK (0.44) | FGFR1MAPTNPSR1 | |
| SCHEMBL11057759 | 0.81 | KCNH3 (0.35) | KCNH3 | |
| SCHEMBL11053159 | 0.81 | ELANE (0.41) | KCNH3EGFRFGFR1DNM2ELANE | |
| SCHEMBL11057771 | 0.80 | FGFR1 (0.46) | KCNH3EGFRFGFR1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |