Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28031798 | 0.80 | MAPK1 (0.45) | MAPK1ALDH1A1L3MBTL1TDP1CASP7 | |
| SCHEMBL12205256 | 0.78 | HTR6 (0.56) | MAPK1ALDH1A1L3MBTL1TDP1CASP7 | |
| SCHEMBL9470270 | 0.78 | ALDH1A1 (0.57) | MAPK1ALDH1A1HTR6MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9469569 | 0.77 | ALDH1A1 (0.56) | MAPK1ALDH1A1HTR6MEN1KMT2A | |
| SCHEMBL397773 | 0.76 | MAPK1 (0.77) | MAPK1ALDH1A1L3MBTL1TDP1CASP7 | |
| SCHEMBL17541409 | 0.75 | ALDH1A1 (0.43) | MAPK1ALDH1A1L3MBTL1TDP1CASP7 | |
| SCHEMBL297021 | 0.72 | MAPK1 (0.60) | MAPK1ALDH1A1L3MBTL1TDP1CASP7 | |
| SCHEMBL355102 | 0.72 | MAPK1 (0.60) | MAPK1ALDH1A1L3MBTL1TDP1CASP7 | |
| SCHEMBL12205174 | 0.72 | MAPK1 (0.60) | MAPK1ALDH1A1L3MBTL1TDP1CASP7 | |
| SCHEMBL856759 | 0.72 | MAPK1 (0.60) | MAPK1ALDH1A1L3MBTL1TDP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4450108-A | ANTIDEPRESSANTS; NEUROLEPTIC AGENTS; PSYCHOLOGICAL DISORDERS | SANDOZ LTD. (CH) | 1984-05-22 | — | — | US | disclosed |
| EP-0031115-A1 | New pyrrolobenzotriazepines, their production and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1981-07-01 | — | — | EP | disclosed |