Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 2/20 | 0.31 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.31 |
| ▸ | SIK1 | P57059 | 2/20 | 0.30 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.30 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.30 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11496851 | 0.93 | SIK1 (0.30) | SIK1SIK2SIK3 | |
| SCHEMBL11058852 | 0.91 | ELANE (0.34) | ELANE | |
| SCHEMBL11053272 | 0.86 | NOS3 (0.32) | ELANE | |
| SCHEMBL11053086 | 0.86 | CHRNA7 (0.33) | EGFRFGFR1SRCWEE1PAK1 | |
| SCHEMBL11060031 | 0.85 | SIK1 (0.33) | EGFRFGFR1SRCSIK1SIK2 | |
| SCHEMBL11052642 | 0.85 | ESR1 (0.38) | EGFRFGFR1SRCWEE1CCNB2 | |
| SCHEMBL11055980 | 0.85 | ELANE (0.31) | ELANESIK1SIK2SIK3 | |
| SCHEMBL11059409 | 0.85 | ELANE (0.31) | ELANESIK1SIK2SIK3 | |
| SCHEMBL11354153 | 0.83 | EGFR (0.36) | EGFRFGFR1SRCPAK1SIK1 | |
| SCHEMBL11058764 | 0.80 | FGFR1 (0.41) | EGFRFGFR1SRCPAK1SIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |