Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK1 | P57059 | 2/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11344723 | 0.91 | NPC1 (0.32) | SIK1SIK2SIK3 | |
| SCHEMBL11053102 | 0.86 | HCAR1 (0.34) | SIK1SIK2SIK3EGFRFGFR1 | |
| SCHEMBL11057711 | 0.85 | EGFR (0.33) | SIK1SIK2SIK3EGFRFGFR1 | |
| SCHEMBL11052642 | 0.85 | ESR1 (0.38) | EGFRFGFR1SRCCCNE2CCNE1 | |
| SCHEMBL11498090 | 0.84 | ESR1 (0.34) | CCNE2CCNE1CDK2 | |
| SCHEMBL11496851 | 0.84 | SIK1 (0.30) | SIK1SIK2SIK3 | |
| SCHEMBL11354153 | 0.83 | EGFR (0.36) | SIK1SIK2SIK3EGFRFGFR1 | |
| SCHEMBL11058764 | 0.80 | FGFR1 (0.41) | SIK1SIK2SIK3EGFRFGFR1 | |
| SCHEMBL11350752 | 0.79 | ALDH1A1 (0.39) | EGFRFGFR1 | |
| SCHEMBL11474313 | 0.79 | MEN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |