Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 6/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.32 |
| ▸ | SIK2 | Q9H0K1 | 3/20 | 0.31 |
| ▸ | SIK1 | P57059 | 2/20 | 0.31 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.31 |
| ▸ | STK4 | Q13043 | 1/20 | 0.30 |
| ▸ | STK3 | Q13188 | 1/20 | 0.30 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.30 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11055502 | 0.91 | AURKA (0.32) | — | |
| SCHEMBL11057711 | 0.86 | EGFR (0.33) | PAK1EGFRFGFR1SRCWEE1 | |
| SCHEMBL11053102 | 0.85 | HCAR1 (0.34) | CHRNA7PAK1EGFRFGFR1SRC | |
| SCHEMBL11053272 | 0.85 | NOS3 (0.32) | — | |
| SCHEMBL11058843 | 0.85 | MAPK14 (0.31) | — | |
| SCHEMBL11054473 | 0.85 | — | — | |
| SCHEMBL11496851 | 0.80 | SIK1 (0.30) | SIK2SIK1SIK3 | |
| SCHEMBL11056407 | 0.79 | CRHR1 (0.34) | CHRNA7EGFRFGFR1SRC | |
| SCHEMBL11054604 | 0.79 | CHRNA7 (0.47) | CHRNA7EGFRFGFR1SRCWEE1 | |
| SCHEMBL11058852 | 0.79 | ELANE (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |