Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057697 | 0.93 | LCK (0.46) | LCKRAB9ANPSR1SMN1; SMN2FGFR1 | |
| SCHEMBL11056787 | 0.93 | LCK (0.43) | KMT2ALCKELANEALDH1A1RAB9A | |
| SCHEMBL11057671 | 0.88 | KMT2A (0.42) | KMT2AMEN1LCKELANEALDH1A1 | |
| SCHEMBL11056764 | 0.88 | CYP1A2 (0.39) | KMT2AMEN1ELANEALDH1A1SMN1; SMN2 | |
| SCHEMBL11057744 | 0.87 | CHRNA7 (0.49) | LCKFGFR1CHRNA7 | |
| SCHEMBL11056389 | 0.85 | ELANE (0.38) | KMT2AMEN1ELANEHTTSMN1; SMN2 | |
| SCHEMBL11056309 | 0.85 | MEN1 (0.36) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL11059426 | 0.84 | KMT2A (0.35) | KMT2AMEN1ALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL11059212 | 0.84 | HCAR1 (0.38) | KMT2AMEN1FGFR1CHRNA7 | |
| SCHEMBL11054558 | 0.83 | HCAR1 (0.34) | KMT2AMEN1TDP1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |