Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 14/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11055055 | 0.91 | CHRNA7 (0.43) | CHRNA7MAPK14FGFR1P2RX7 | |
| SCHEMBL11053517 | 0.90 | TDP1 (0.38) | CHRNA7MAPK14FGFR1P2RX7 | |
| SCHEMBL11056309 | 0.89 | MEN1 (0.36) | CHRNA7P2RX7 | |
| SCHEMBL11057686 | 0.88 | MAOA (0.35) | CHRNA7P2RX7 | |
| SCHEMBL11497315 | 0.87 | MKNK1 (0.39) | MAPK14FGFR1P2RX7 | |
| SCHEMBL11050220 | 0.86 | SMN1; SMN2 (0.43) | CHRNA7MAPK14FGFR1 | |
| SCHEMBL11057744 | 0.85 | CHRNA7 (0.49) | CHRNA7MAPK14FGFR1 | |
| SCHEMBL11055490 | 0.85 | MAOA (0.38) | P2RX7 | |
| SCHEMBL11050309 | 0.82 | CHRNA7 (0.43) | CHRNA7MAPK14FGFR1 | |
| SCHEMBL11059426 | 0.80 | KMT2A (0.35) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |