SCHEMBL110581

SCHEMBL110581

C[C@](O)(CBr)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 7/20 0.68
CYP2C19 P33261 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29504171 1.00 AR (0.68) ARCYP2C19
SCHEMBL14517806 1.00 AR (0.68) ARCYP2C19
SCHEMBL4279811 1.00 AR (0.68) ARCYP2C19
SCHEMBL28379214 0.93 AR (0.67) AR
SCHEMBL28379213 0.93 AR (0.67) AR
SCHEMBL13167763 0.90 AR (0.65) AR
SCHEMBL19243489 0.89 AR (0.69) ARCYP2C19
SCHEMBL20113379 0.89 AR (0.69) ARCYP2C19
SCHEMBL14878986 0.89 AR (0.69) ARCYP2C19
SCHEMBL5363230 0.89 AR (0.69) ARCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 320 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111138353-A Nicotinate hydrate and preparation method thereof 宁波耆健医药科技有限公司 2020-05-12 CN claimed
CN-110981794-A Synthetic method of nicotinate 宁波耆健医药科技有限公司 2020-04-10 CN claimed
US-12398121-B2 Anti-cancer nuclear hormone receptor-targeting compounds NUVATION BIO INC. (US) 2025-08-26 US disclosed
US-12215086-B2 Selective androgen receptor degrader (SARD) ligands and methods of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2025-02-04 US disclosed
US-12208141-B2 Anti-cancer nuclear hormone receptor-targeting compounds NUVATION BIO INC. (US) 2025-01-28 US disclosed
US-12202815-B2 Selective androgen receptor degrader (SARD) ligands and methods of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2025-01-21 US disclosed
US-12128026-B2 Selective androgen receptor degrader (SARD) ligands and methods of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2024-10-29 US disclosed
US-12115146-B2 Treatment of skeletal-related events for breast cancer patients UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2024-10-15 US disclosed
US-20240326697-A1 SOLID FORMS OF SELECTIVE ANDROGEN RECEPTOR MODULATORS UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2024-10-03 US disclosed
US-12053448-B2 Solid forms of selective androgen receptor modulators UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2024-08-06 US disclosed
US-20240181066-A1 ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) 2024-06-06 US disclosed
US-20070173546-A1 Selective androgen receptor modulators and method of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-07-26 US disclosed
US-20070161608-A1 Selective androgen receptor modulators for treating muscle wasting UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-07-12 US disclosed
US-20070161608-A1 Selective androgen receptor modulators for treating muscle wasting UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-07-12 US disclosed
US-20070123563-A1 Selective androgen receptor modulators and method of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-05-31 US disclosed
US-20070123563-A1 Selective androgen receptor modulators and method of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-05-31 US disclosed
US-20070066568-A1 Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-03-22 US disclosed
US-20070066568-A1 Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-03-22 US disclosed
WO-2007027582-A2 TREATING RENAL DISEASE, BURNS, WOUNDS AND SPINAL CORD INJURY WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2007-03-08 WO disclosed
WO-2007027582-A2 TREATING RENAL DISEASE, BURNS, WOUNDS AND SPINAL CORD INJURY WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2007-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12208141-B2 Anti-cancer nuclear hormone receptor-targeting compounds NCOA1, NCOR1, NCOA3 AR 9/4885CYP2C19 4495/4885
US-12398121-B2 Anti-cancer nuclear hormone receptor-targeting compounds NCOA1, NCOR1, NCOA3 AR 9/4885CYP2C19 4495/4885
US-20240181066-A1 ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS NCOA1, NCOR1, NCOA3 AR 9/4885CYP2C19 4495/4885
US-20070173546-A1 Selective androgen receptor modulators and method of use thereof AR, SHBG, ESRRA AR 1/4885CYP2C19 2245/4885
US-12115146-B2 Treatment of skeletal-related events for breast cancer patients AR, PGR, GNRHR AR 1/4885CYP2C19 603/4885
US-20070066568-A1 Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators AR, SARM1, OPRM1 AR 1/4885CYP2C19 164/4885
US-12215086-B2 Selective androgen receptor degrader (SARD) ligands and methods of use thereof AR, BRCA1, AHR AR 1/4885CYP2C19 848/4885
US-20070123563-A1 Selective androgen receptor modulators and method of use thereof AR, SHBG, ESRRA AR 1/4885CYP2C19 2245/4885
US-12128026-B2 Selective androgen receptor degrader (SARD) ligands and methods of use thereof AR, AHR, BRDT AR 1/4885CYP2C19 1798/4885
US-20070161608-A1 Selective androgen receptor modulators for treating muscle wasting AR, ESRRA, SHBG AR 1/4885CYP2C19 3467/4885
US-12053448-B2 Solid forms of selective androgen receptor modulators AR, FSHR, NR5A1 AR 1/4885CYP2C19 567/4885
US-12202815-B2 Selective androgen receptor degrader (SARD) ligands and methods of use thereof AR, BRCA1, FSHR AR 1/4885CYP2C19 1596/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.