Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847111 | 0.91 | ALDH1A1 (0.53) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL11834098 | 0.91 | GPR35 (0.50) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL11836929 | 0.90 | GPR35 (0.49) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL11244993 | 0.90 | KDM4E (0.65) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL3866 | 0.89 | GPR35 (0.79) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL11237289 | 0.89 | GPR35 (0.79) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL13243157 | 0.86 | GPR35 (0.59) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL18211454 | 0.86 | GPR35 (0.59) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL11834789 | 0.85 | KDM4E (0.60) | GPR35LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL11461642 | 0.85 | GPR35 (0.54) | GPR35LMNATDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4461769-A | ANTIASTHEMIC AGENTS-PYRIDO(1,2-A)PYRIMIDINE COMPOUNDS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) | 1984-07-24 | — | — | US | disclosed |
| US-4456752-A | REACTING A HYDRAZINE WITH DIHALOGEN SUBSTITUTED PYRIDO(1,2-A)PYRIMIDINE | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) | 1984-06-26 | — | — | US | disclosed |
| US-4452982-A | Process for the preparation of nitrogen-bridgehead condensed pyrimidine compounds, and pharmaceutical compositions containing them | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) | 1984-06-05 | — | — | US | disclosed |
| US-4362742-A | TOPICAL APPLICATION | SULLIVAN THOMAS J | 1982-12-07 | — | — | US | disclosed |
| US-4271182-A | TOPICAL APPLICATION OF 1,3-BIS((2-CARBOXY-CHROMON-5-)OXY)-2-HYDROXYPROPANE | FISONS LIMITED (GB) | 1981-06-02 | — | — | US | disclosed |
| US-4260612-A | Antiallergic nitrogen bridge-head compounds | CHINOIN GYOGYSZER ES VECYESZETI TERMEKEK GYARA RT. (HU) | 1981-04-07 | — | — | US | disclosed |
| US-4234586-A | ASTHMA; 9-HYDRAZONO-4H-PYRIDO(1,2A)PYRIMIDINE DERIVATIVES | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1980-11-18 | — | — | US | disclosed |
| US-4152448-A | ANTIINFLAMMATORY | FISONS LIMITED (GB) | 1979-05-01 | — | — | US | disclosed |
| US-4066766-A | 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents | PFIZER INC. (US) | 1978-01-03 | — | — | US | disclosed |