Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056376 | 0.94 | MKNK1 (0.36) | MEN1KMT2AMKNK1MKNK2TMIGD3 | |
| SCHEMBL11059426 | 0.90 | KMT2A (0.35) | MEN1KMT2AMKNK1MKNK2TMIGD3 | |
| SCHEMBL11060192 | 0.85 | MKNK1 (0.36) | MEN1KMT2AMKNK1MKNK2ALDH1A1 | |
| SCHEMBL11057671 | 0.85 | KMT2A (0.42) | MEN1KMT2ACHRNA7ALDH1A1SMN1; SMN2 | |
| SCHEMBL11059488 | 0.84 | MKNK1 (0.37) | KMT2AMKNK1MKNK2TMIGD3ADORA2A | |
| SCHEMBL11056309 | 0.82 | MEN1 (0.36) | MEN1KMT2AMKNK1MKNK2CHRNA7 | |
| SCHEMBL11055055 | 0.80 | CHRNA7 (0.43) | MKNK2CHRNA7 | |
| SCHEMBL11052481 | 0.80 | MKNK1 (0.34) | KMT2AMKNK1MKNK2CHRNA7ALDH1A1 | |
| SCHEMBL11053577 | 0.78 | MKNK1 (0.47) | MEN1KMT2AMKNK1MKNK2ADORA2A | |
| SCHEMBL11056312 | 0.78 | LCK (0.44) | MEN1KMT2AMKNK1TMIGD3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |