Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 3/20 | 0.36 |
| ▸ | CASP7 | P55210 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11059426 | 0.94 | KMT2A (0.35) | MKNK1MKNK2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11055490 | 0.90 | MAOA (0.38) | MKNK1MKNK2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11056376 | 0.90 | MKNK1 (0.36) | MKNK1MKNK2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11052481 | 0.85 | MKNK1 (0.34) | MKNK1MKNK2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11055055 | 0.85 | CHRNA7 (0.43) | MKNK2P2RX7 | |
| SCHEMBL11056309 | 0.85 | MEN1 (0.36) | MKNK1MKNK2ALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL11059487 | 0.84 | MEN1 (0.36) | MKNK1MKNK2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11053517 | 0.84 | TDP1 (0.38) | MKNK1MKNK2MAOAMAOBP2RX7 | |
| SCHEMBL11052662 | 0.83 | MKNK1 (0.49) | MKNK1MKNK2CYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL11057697 | 0.83 | LCK (0.46) | MKNK1HPGDCASP1CASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |