Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCND2 | P30279 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056376 | 0.91 | MKNK1 (0.36) | MKNK1MKNK2SMN1; SMN2LCKALDH1A1 | |
| SCHEMBL11055490 | 0.89 | MAOA (0.38) | MKNK1MKNK2MAOAMAOBGBA1 | |
| SCHEMBL11059487 | 0.85 | MEN1 (0.36) | MKNK1MKNK2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11053577 | 0.85 | MKNK1 (0.47) | MKNK1MKNK2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11056312 | 0.84 | LCK (0.44) | MKNK1SMN1; SMN2LCKALDH1A1MEN1 | |
| SCHEMBL11056309 | 0.84 | MEN1 (0.36) | MKNK1MKNK2MAOAMAOBGBA1 | |
| SCHEMBL11053517 | 0.83 | TDP1 (0.38) | MKNK1MKNK2MAOAMAOB | |
| SCHEMBL11059488 | 0.80 | MKNK1 (0.37) | MKNK1MKNK2MAOAMAOBSMN1; SMN2 | |
| SCHEMBL11497315 | 0.80 | MKNK1 (0.39) | MKNK1MKNK2MAOAMAOBSMN1; SMN2 | |
| SCHEMBL11054993 | 0.79 | KCNH2 (0.38) | SMN1; SMN2ALDH1A1MEN1KMT2ACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |