Noreximide

Noreximide

SCHEMBL1105956

O=C1NC(=O)[C@H]2C3C=CC(C3)[C@@H]12

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
TDP1 Q9NUW8 2/20 0.48
RAB9A P51151 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
HTT P42858 2/20 0.41
LMNA P02545 1/20 0.41
RECQL P46063 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.39
POLB P06746 1/20 0.39
PKM P14618 1/20 0.39
USP2 O75604 2/20 0.38
TSHR P16473 2/20 0.38
HSD17B10 Q99714 1/20 0.38
KDM4E B2RXH2 2/20 0.37
MAPK1 P28482 1/20 0.37
MAPT P10636 2/20 0.37
CYP3A4 P08684 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Noreximide SCHEMBL16664270 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
Noreximide SCHEMBL2109030 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
Noreximide SCHEMBL572054 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
Noreximide SCHEMBL14536593 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
Noreximide SCHEMBL339739 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
Noreximide SCHEMBL24120970 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
Noreximide SCHEMBL17369118 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
Noreximide SCHEMBL9073180 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
Noreximide SCHEMBL17875126 1.00 ALDH1A1 (0.48) ALDH1A1TDP1RAB9AMEN1KMT2A
SCHEMBL16275149 0.88 ALDH1A1 (0.39) ALDH1A1TDP1RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0343108-B1 Resin compositions CIBA GEIGY AG (CH) 1994-08-31 EP claimed
US-4981888-A Resin compositions CIBA-GEIGY CORPORATION (US) 1991-01-01 US claimed
US-9382387-B2 Rapid self-assembly of block copolymers to photonic crystals CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-07-05 US disclosed
US-20160024244-A1 Periodic Nanostructures From Self Assembled Wedge-Type Block-Copolymers NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-01-28 US disclosed
US-9045579-B2 Periodic nanostructures from self assembled wedge-type block-copolymers CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-06-02 US disclosed
US-20130296491-A1 Periodic Nanostructures From Self Assembled Wedge-Type Block-Copolymers NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2013-11-07 US disclosed
US-8450419-B2 Blend of diene polymer, thermoplastic or thermoset polymer; unsaturated acid or anhydride interpolymers, and a mixture of two different metal compounds capable or forming mixed ionomers of the polymers; injection moldable BRIDGESTONE SPORTS CO., LTD. (JP) 2013-05-28 US disclosed
US-8445611-B2 Antimicrobial polymers UNIVERSITY OF MASSACHUSETTS (US) 2013-05-21 US disclosed
US-8288476-B2 Golf ball material, golf ball and method for preparing golf ball material BRIDGESTONE SPORTS CO., LTD. (JP) 2012-10-16 US disclosed
US-20120195849-A1 ANTIMICROBIAL POLYMERS MIDCAP FINANCIAL SBIC, LP, AS ADMINISTRATIVE AGENT 2012-08-02 US disclosed
US-8153739-B2 Antimicrobial polymers UNIVERSITY OF MASSACHUSETTS (US) 2012-04-10 US disclosed
US-7700689-B2 Golf ball material, golf ball and method for preparing golf ball material BRIDGESTONE SPORTS CO., LTD. (JP) 2010-04-20 US disclosed
US-7635730-B2 neutralization of carboxyl containing unsaturated copolymer grafting of unsaturated anhydride in one step using organometallic chelating agent such as edta, tetrapotassium salt or mixed with alkali or alkaline or zinc metal oxide/ hydroxide/carbonates; materbatch; durability, scuff resistance; ionomers BRIDGESTONE SPORTS CO., LTD. (JP) 2009-12-22 US disclosed
US-20090281244-A2 Golf Ball Material, Golf Ball And Method For Preparing Golf Ball Material BRIDGESTONE SPORTS CO., LTD. (JP) 2009-11-12 US disclosed
US-20080161456-A1 neutralization of carboxyl containing unsaturated copolymer grafting of unsaturated anhydride in one step using organometallic chelating agent such as edta, tetrapotassium salt or mixed with alkali or alkaline or zinc metal oxide/ hydroxide/carbonates; materbatch; durability, scuff resistance; ionomers BRIDGESTONE SPORTS CO., LTD. (JP) 2008-07-03 US disclosed
US-20080021161-A1 Golf ball material, golf ball and method for preparing golf ball material BRIDGESTONE CORPORATION 2008-01-24 US disclosed
US-20070282069-A1 Golf ball material, golf ball and method for preparing golf ball material BRIDGESTONE SPORTS CO., LTD. 2007-12-06 US disclosed
US-4981888-A Resin compositions CIBA-GEIGY CORPORATION (US) 1991-01-01 US disclosed
US-4945170-A Method for making polyimides and products produced thereby AMERICAN CYANAMID COMPANY (US) 1990-07-31 US disclosed
US-4608431-A SIMPLE ONE-STEP REACTION OF MALEIMIDE, FORMALDEHYDE AND POLYAMINE TO FORM ADDITION POLYMERIZABLE MONOMER AMERICAN CYANAMID CO. (US) 1986-08-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120195849-A1 ANTIMICROBIAL POLYMERS CGAS, NOD2, NLRP1 ALDH1A1 4035/4885TDP1 3005/4885RAB9A 2939/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.