Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 5/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10985618 | 0.83 | MEN1 (0.49) | KDM4ECA2STK4ALDH1A1KMT2A | |
| SCHEMBL6197961 | 0.82 | KDM4E (0.43) | KDM4EHSD17B10EGFRBRD4BRD2 | |
| SCHEMBL9592356 | 0.77 | EGFR (0.45) | KDM4EHSD17B10EGFRCA2ASPH | |
| SCHEMBL3871505 | 0.74 | EGFR (0.50) | EGFRCSF1RNUDT1 | |
| Hydrochloric Acid SCHEMBL6084967 | 0.73 | EGFR (0.49) | EGFRCSF1RNUDT1 | |
| SCHEMBL10373576 | 0.72 | TP53 (0.36) | KDM4EHSD17B10EGFRBRD4BRD2 | |
| SCHEMBL1645669 | 0.71 | KIF11 (0.38) | KDM4EASPHMELKALDH1A1KMT2A | |
| SCHEMBL8529466 | 0.71 | KDM4E (0.54) | KDM4EHSD17B10HDAC1HDAC6CA1 | |
| SCHEMBL398640 | 0.71 | DHODH (0.47) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL5767408 | 0.71 | KEAP1 (0.42) | KDM4EHSD17B10CA1CA2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0134165-A2 | 7-(Pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 7-(pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives, their preparation and use as medicaments | PROVESAN S.A. (CH) | 1985-03-13 | — | — | EP | disclosed |