SCHEMBL11059892

SCHEMBL11059892

O=C1CCSC(c2cccnc2)N1C1CCCCC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
CYP11B2 P19099 1/20 0.46
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
NPSR1 Q6W5P4 3/20 0.45
MAPT P10636 2/20 0.44
KDM4E B2RXH2 2/20 0.44
CYP3A4 P08684 1/20 0.44
THRB P10828 1/20 0.44
TSHR P16473 1/20 0.44
THPO P40225 1/20 0.44
MAPK1 P28482 1/20 0.44
CACNA1B Q00975 2/20 0.43
TDP1 Q9NUW8 1/20 0.42
POLB P06746 3/20 0.42
CYP2D6 P10635 2/20 0.42
CYP2C19 P33261 2/20 0.42
CHRNB2 P17787 1/20 0.42
CHRNA7 P36544 1/20 0.42
CHRNA4 P43681 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11058008 0.99 ALDH1A1 (0.47) ALDH1A1CYP11B2MEN1KMT2ANPSR1
SCHEMBL11054462 0.87 NPSR1 (0.60) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL11052968 0.86 ALDH1A1 (0.59) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL11056130 0.80 ALDH1A1 (0.61) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL11055908 0.78 CYP11B2 (0.46) ALDH1A1CYP11B2MEN1KMT2ANPSR1
Cyclopentane SCHEMBL11118549 0.78 ALDH1A1 (0.46) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL11057270 0.78 CYP11B2 (0.46) ALDH1A1CYP11B2MEN1KMT2ANPSR1
Hydrochloric Acid SCHEMBL11054142 0.77 CYP11B2 (0.44) ALDH1A1CYP11B2MEN1KMT2ANPSR1
SCHEMBL25029976 0.75 KDM4E (0.63) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL11118545 0.75 MAPT (0.54) ALDH1A1MEN1KMT2ANPSR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4482712-A FUNGICIDES; HERBICIDES; PLANT GROWTH REGULATORS ELI LILLY AND COMPANY (US) 1984-11-13 US disclosed
EP-0010420-B1 PYRIDYL-SUBSTITUTED THIAZOLIDINE AND 1,3-THIAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AGRICULTURAL COMPOSITIONS CONTAINING SAID DERIVATIVES AND METHODS FOR REGULATING PLANT GROWTH AND PROTECTING PLANTS FROM FUNGI ELI LILLY AND COMPANY (US) 1984-08-22 EP disclosed
US-4436739-A FUNGICIDES ELI LILLY AND COMPANY (US) 1984-03-13 US disclosed