Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11286922 | 0.86 | SCN5A (0.34) | ALDH1A1MAPTGAAHPGDMEN1 | |
| SCHEMBL11142252 | 0.83 | HTT (0.50) | ALDH1A1MAPTGAAPKMSMN1; SMN2 | |
| SCHEMBL11056545 | 0.83 | SCN5A (0.42) | ALDH1A1MAPTGAAHPGDRAB9A | |
| Hydrochloric Acid SCHEMBL11141377 | 0.82 | HTT (0.49) | ALDH1A1MAPTGAAPKMSMN1; SMN2 | |
| SCHEMBL30012866 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTGAAPKMSMN1; SMN2 | |
| SCHEMBL11138593 | 0.76 | ALDH1A1 (0.33) | ALDH1A1MAPTGAAPKMSMN1; SMN2 | |
| SCHEMBL25197342 | 0.75 | GAA (0.42) | ALDH1A1MAPTGAAPKMSMN1; SMN2 | |
| SCHEMBL11141474 | 0.75 | ALDH1A1 (0.35) | ALDH1A1MAPTGAAPKMSMN1; SMN2 | |
| SCHEMBL11052899 | 0.73 | ALDH1A1 (0.60) | ALDH1A1MAPTGAAPKMSMN1; SMN2 | |
| SCHEMBL11279063 | 0.71 | ALDH1A1 (0.37) | ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4418209-A | ANTIULCER, ANTIARRYTHMIC, ANTIDIARRHEAL, ANTISPASMODIC, ANTIPARASITIC, AND ANTISECRETORY AGENTS | WILLIAM H. RORER, INC. (US) | 1983-11-29 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |