Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057721 | 0.85 | ALDH1A1 (0.41) | ALDH1A1HPGDLMNANLRP3PLK1 | |
| SCHEMBL11286922 | 0.85 | SCN5A (0.34) | ALDH1A1HPGDLMNAPLK1 | |
| SCHEMBL11277645 | 0.84 | ALDH1A1 (0.53) | ALDH1A1RAPGEF4HPGDLMNANLRP3 | |
| SCHEMBL11274093 | 0.81 | ALDH1A1 (0.44) | ALDH1A1RAPGEF4HPGDLMNANLRP3 | |
| SCHEMBL11287194 | 0.77 | POLB (0.42) | ALDH1A1LMNA | |
| SCHEMBL11278705 | 0.74 | ALDH1A1 (0.50) | ALDH1A1HPGDNLRP3 | |
| SCHEMBL11412554 | 0.73 | TSHR (0.40) | ALDH1A1HPGDLMNA | |
| SCHEMBL18495129 | 0.72 | RAPGEF4 (0.41) | ALDH1A1RAPGEF4HPGDPLK1 | |
| SCHEMBL11557047 | 0.72 | SCN5A (0.49) | ALDH1A1LMNANLRP3 | |
| SCHEMBL11056545 | 0.72 | SCN5A (0.42) | ALDH1A1HPGDLMNAPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |