Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056954 | 0.89 | KMT2A (0.58) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL11061130 | 0.86 | KMT2A (0.79) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL11065237 | 0.80 | MEN1 (0.81) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL11056958 | 0.74 | RAB9A (0.50) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL5738724 | 0.73 | KDM4E (0.60) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL11061195 | 0.73 | POLB (0.52) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL5739701 | 0.71 | ADORA2A (0.60) | KMT2AMEN1ALDH1A1HPGDHTR1A | |
| SCHEMBL5740424 | 0.69 | KDM4E (0.59) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL11448423 | 0.69 | DRD4 (0.47) | KMT2AMEN1ALDH1A1KDM4EALOX12 | |
| SCHEMBL7502792 | 0.69 | XIAP (0.42) | KMT2AMEN1ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446323-A | Tetra- and hexa-hydropyrrolo(1,2-a)quinoxaline and azaquinoxaline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-05-01 | — | — | US | claimed |
| US-4446323-A | Tetra- and hexa-hydropyrrolo(1,2-a)quinoxaline and azaquinoxaline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-05-01 | — | — | US | disclosed |