Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11061130 | 0.92 | KMT2A (0.79) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL11056954 | 0.84 | KMT2A (0.58) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL11061243 | 0.80 | KMT2A (0.60) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL11055326 | 0.80 | MEN1 (0.66) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL11056923 | 0.79 | KMT2A (0.64) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL5738724 | 0.77 | KDM4E (0.60) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL5739701 | 0.75 | ADORA2A (0.60) | MEN1KMT2AALDH1A1HPGDADORA2A | |
| SCHEMBL5740424 | 0.73 | KDM4E (0.59) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL31435145 | 0.69 | THRB (0.55) | MAPTHTR1A | |
| SCHEMBL1021890 | 0.67 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446323-A | Tetra- and hexa-hydropyrrolo(1,2-a)quinoxaline and azaquinoxaline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-05-01 | — | — | US | claimed |
| US-4446323-A | Tetra- and hexa-hydropyrrolo(1,2-a)quinoxaline and azaquinoxaline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-05-01 | — | — | US | disclosed |