Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11059523 | 0.82 | ALDH1A1 (0.34) | HTTALDH1A1KMT2ATDP1 | |
| SCHEMBL11069778 | 0.81 | ALDH1A1 (0.36) | HTTCYP1A2ALDH1A1KMT2ATDP1 | |
| SCHEMBL10957823 | 0.78 | ALDH1A1 (0.37) | HTTCYP1A2ALDH1A1KMT2ATDP1 | |
| SCHEMBL11065024 | 0.77 | LMNA (0.46) | HTTALDH1A1KMT2ATDP1 | |
| SCHEMBL11062426 | 0.77 | MAPT (0.34) | KMT2A | |
| SCHEMBL11062612 | 0.74 | HTT (0.35) | HTTCYP1A2ALDH1A1KMT2ATDP1 | |
| SCHEMBL11062434 | 0.72 | MAPT (0.36) | HTTCYP1A2ALDH1A1 | |
| SCHEMBL29261699 | 0.71 | CCR4 (0.33) | HTTCYP1A2ALDH1A1KMT2A | |
| SCHEMBL11055958 | 0.70 | HTT (0.40) | HTTCYP1A2ALDH1A1KMT2ATDP1 | |
| SCHEMBL11058164 | 0.69 | ALDH1A1 (0.41) | HTTCYP1A2ALDH1A1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |