Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957823 | 0.88 | ALDH1A1 (0.37) | LMNAHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11058765 | 0.78 | ADORA3 (0.34) | LMNAHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11061561 | 0.77 | HTT (0.33) | TDP1HTTALDH1A1KMT2A | |
| SCHEMBL11062612 | 0.74 | HTT (0.35) | CYP2C19TDP1HTTALDH1A1KMT2A | |
| SCHEMBL11059523 | 0.72 | ALDH1A1 (0.34) | TDP1HTTALDH1A1KMT2A | |
| SCHEMBL11069778 | 0.71 | ALDH1A1 (0.36) | TDP1HTTALDH1A1KMT2A | |
| SCHEMBL29261699 | 0.71 | CCR4 (0.33) | LMNACYP2C19HTTALDH1A1KMT2A | |
| SCHEMBL11055958 | 0.70 | HTT (0.40) | CYP2C19TDP1HTTALDH1A1KMT2A | |
| SCHEMBL11058164 | 0.69 | ALDH1A1 (0.41) | LMNATDP1HTTALDH1A1KMT2A | |
| SCHEMBL11058685 | 0.68 | L3MBTL1 (0.40) | LMNACYP2C19HTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |