Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8248373 | 0.85 | RNF4 (0.47) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL11063095 | 0.81 | ALDH1A1 (0.44) | L3MBTL1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL11062234 | 0.80 | ALDH1A1 (0.43) | L3MBTL1NPC1RAB9AALDH1A1HTT | |
| SCHEMBL11065640 | 0.80 | ALDH1A1 (0.43) | L3MBTL1MAPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL11068842 | 0.79 | LTB4R2 (0.41) | KMT2ARAB9AALDH1A1PTGDR2MAPT | |
| SCHEMBL11065506 | 0.79 | L3MBTL1 (0.50) | L3MBTL1ALDH1A1LMNA | |
| SCHEMBL29837176 | 0.75 | ALDH1A1 (0.39) | L3MBTL1MAPK1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL11071581 | 0.73 | ALDH1A1 (0.47) | L3MBTL1MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL5729903 | 0.72 | ALDH1A1 (0.43) | L3MBTL1MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL3075543 | 0.71 | ABCB1 (0.46) | L3MBTL1MAPK1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447436-A | 1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1-methylanilino and use as smooth muscle relaxants | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-05-08 | — | — | US | disclosed |
| US-4220647-A | MUSCLE RELAXANTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-09-02 | — | — | US | disclosed |