SCHEMBL11063142

SCHEMBL11063142

COC(=O)c1ccccc1C(=O)NN(C)C(=S)Nc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.47
MEN1 O00255 4/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
POLB P06746 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MAPT P10636 5/20 0.46
ALOX15 P16050 1/20 0.46
LMNA P02545 6/20 0.45
ALDH1A1 P00352 5/20 0.45
GAA P10253 4/20 0.44
HPGD P15428 2/20 0.44
RAB9A P51151 1/20 0.44
KDM4E B2RXH2 1/20 0.44
ALOX12 P18054 1/20 0.44
HIF1A Q16665 1/20 0.43
NPC1 O15118 1/20 0.42
HTT P42858 1/20 0.41
EPHX1 P07099 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11067057 0.87 ALDH1A1 (0.58) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL11074428 0.87 ALDH1A1 (0.47) KMT2ASMN1; SMN2MAPTLMNAALDH1A1
SCHEMBL11074384 0.87 GAA (0.48) KMT2AMEN1SMN1; SMN2MAPTLMNA
SCHEMBL11244383 0.86 ALDH1A1 (0.57) KMT2AMEN1POLBALDH1A1HPGD
Ammonia Solution, Strong SCHEMBL11230287 0.86 ALDH1A1 (0.57) KMT2AMEN1POLBALDH1A1HPGD
Ammonia Solution, Strong SCHEMBL11230292 0.86 ALDH1A1 (0.57) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL11063673 0.85 MASP2 (0.44) KMT2AMEN1SMN1; SMN2MAPTLMNA
SCHEMBL11185293 0.84 ALDH1A1 (0.45) KMT2AMEN1SMN1; SMN2POLBL3MBTL1
Potassium Ion SCHEMBL11244388 0.84 ALDH1A1 (0.43) KMT2AMEN1MAPTLMNAALDH1A1
SCHEMBL11066195 0.83 KMT2A (0.44) KMT2AMEN1SMN1; SMN2POLBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0009324-B1 SUBSTITUTED 1-BENZOYL-3-THIOSEMICARBAZIDES, THEIR MANUFACTURE AND USE AS PLANT GROWTH REGULANTS, AND AGRICULTURAL FORMULATIONS COMPRISING THEM Gulf Oil Corporation (US) 1982-07-21 EP claimed
EP-0021663-A1 A polyheterocyclic compound, its preparation and a smoking composition in which it is used PHILIP MORRIS INCORPORATED (US) 1981-01-07 EP claimed
EP-0009324-A1 Substituted 1-benzoyl-3-thiosemicarbazides, their manufacture and use as plant growth regulants, and agricultural formulations comprising them Gulf Oil Corporation (US) 1980-04-02 EP claimed
US-4462821-A 1-BENZOYL-3-THIOSEMICARBAZIDFES GULF OIL CORPORATION (US) 1984-07-31 US disclosed
EP-0009324-B1 SUBSTITUTED 1-BENZOYL-3-THIOSEMICARBAZIDES, THEIR MANUFACTURE AND USE AS PLANT GROWTH REGULANTS, AND AGRICULTURAL FORMULATIONS COMPRISING THEM Gulf Oil Corporation (US) 1982-07-21 EP disclosed
US-4339382-A Process for manufacturing N-arylthiocarbamoyl-2-amino-1H-isoindole-1,3-(2H)diones GULF OIL CORPORATION (US) 1982-07-13 US disclosed
US-4282031-A Substituted thiosemicarbazides, their manufacture and use as plant growth regulants GULF OIL CORPORATION (US) 1981-08-04 US disclosed
EP-0023766-A1 Phenyliminothiadiazolines, a method for manufacturing them and their application for regulating growth of plants Gulf Oil Corporation (US) 1981-02-11 EP disclosed
EP-0016571-A1 N-(Arylthiocarbamoyl)-2-amino-1H-isoindole-1,3-(2H)diones, processes for their preparation and their use as plant growth regulators Gulf Oil Corporation (US) 1980-10-01 EP disclosed
EP-0009324-A1 Substituted 1-benzoyl-3-thiosemicarbazides, their manufacture and use as plant growth regulants, and agricultural formulations comprising them Gulf Oil Corporation (US) 1980-04-02 EP disclosed