Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11067057 | 0.87 | ALDH1A1 (0.58) | ALDH1A1HPGDEPHX1MASP2MEN1 | |
| SCHEMBL11244383 | 0.86 | ALDH1A1 (0.57) | ALDH1A1HPGDEPHX1MASP2MEN1 | |
| Ammonia Solution, Strong SCHEMBL11230292 | 0.86 | ALDH1A1 (0.57) | ALDH1A1HPGDEPHX1MASP2MEN1 | |
| Ammonia Solution, Strong SCHEMBL11230287 | 0.86 | ALDH1A1 (0.57) | ALDH1A1HPGDEPHX1MASP2MEN1 | |
| SCHEMBL11063673 | 0.85 | MASP2 (0.44) | ALDH1A1HPGDEPHX1MASP2LMNA | |
| SCHEMBL11063142 | 0.84 | KMT2A (0.47) | ALDH1A1HPGDEPHX1LMNAMAPT | |
| SCHEMBL11074428 | 0.80 | ALDH1A1 (0.47) | ALDH1A1HPGDLMNATDP1MAPT | |
| SCHEMBL11401008 | 0.79 | ALDH1A1 (0.55) | ALDH1A1EPHX1MASP2LMNAMAPT | |
| SCHEMBL11236170 | 0.79 | LMNA (0.48) | ALDH1A1HPGDEPHX1MASP2LMNA | |
| SCHEMBL11185293 | 0.77 | ALDH1A1 (0.45) | ALDH1A1HPGDLMNATDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009324-B1 | SUBSTITUTED 1-BENZOYL-3-THIOSEMICARBAZIDES, THEIR MANUFACTURE AND USE AS PLANT GROWTH REGULANTS, AND AGRICULTURAL FORMULATIONS COMPRISING THEM | Gulf Oil Corporation (US) | 1982-07-21 | — | — | EP | disclosed |