Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7684712 | 0.79 | ELANE (0.44) | MAPTMAPK1ALOX5SMN1; SMN2KMT2A | |
| SCHEMBL11064982 | 0.79 | ALOX5 (0.46) | MAPTMAPK1ALOX5SMN1; SMN2KMT2A | |
| SCHEMBL11059882 | 0.79 | ALOX5 (0.46) | MAPTMAPK1ALOX5SMN1; SMN2KMT2A | |
| SCHEMBL7674450 | 0.78 | LMNA (0.42) | MAPTSMN1; SMN2KMT2ALMNAHPGD | |
| SCHEMBL11063907 | 0.76 | ALOX5 (0.43) | MAPTMAPK1ALOX5SMN1; SMN2KMT2A | |
| SCHEMBL406058 | 0.74 | MAOB (0.58) | MAPTMAPK1ALOX5SMN1; SMN2KMT2A | |
| SCHEMBL11198914 | 0.74 | ALOX5 (0.56) | MAPTMAPK1ALOX5SMN1; SMN2KMT2A | |
| SCHEMBL11068597 | 0.72 | ALOX5 (0.47) | MAPTMAPK1ALOX5SMN1; SMN2KMT2A | |
| SCHEMBL7678852 | 0.71 | LMNA (0.51) | MAPTSMN1; SMN2KMT2ALMNAHPGD | |
| SCHEMBL11071958 | 0.71 | ALOX5 (0.53) | MAPTMAPK1ALOX5SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4440779-A | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |