Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.56 |
| ▸ | DRD3 | P35462 | 9/20 | 0.56 |
| ▸ | DRD4 | P21917 | 7/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 8/20 | 0.54 |
| ▸ | MAOB | P27338 | 8/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065052 | 0.93 | MAOA (0.61) | DRD2DRD3DRD4MAOAMAOB | |
| SCHEMBL11066559 | 0.91 | DRD2 (0.59) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL11070987 | 0.89 | DRD2 (0.60) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL11064821 | 0.84 | MAOA (0.65) | DRD2DRD3DRD4MAOAMAOB | |
| SCHEMBL11065756 | 0.84 | KDM1A (0.55) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL11070211 | 0.83 | DRD2 (0.65) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL11070110 | 0.82 | S1PR5 (0.47) | DRD2DRD3DRD4HTR7 | |
| SCHEMBL11068976 | 0.82 | S1PR5 (0.47) | DRD2DRD3DRD4HTR7 | |
| SCHEMBL11062767 | 0.81 | MAOA (0.66) | DRD2DRD3DRD4MAOAMAOB | |
| SCHEMBL23097595 | 0.77 | DRD2 (0.81) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |