Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26621753 | 1.00 | KEAP1 (0.60) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| Hydrochloric Acid SCHEMBL10978 | 0.98 | KEAP1 (0.58) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| Hydrochloric Acid SCHEMBL23116183 | 0.95 | KEAP1 (0.56) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL2746864 | 0.93 | KEAP1 (0.58) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL11536090 | 0.91 | SMN1; SMN2 (0.56) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| Bicarbonate SCHEMBL28180070 | 0.86 | LMNA (0.49) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL8997786 | 0.84 | KEAP1 (0.46) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL40041 | 0.84 | — | — | |
| SCHEMBL1998867 | 0.84 | KEAP1 (0.71) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL7239607 | 0.84 | KEAP1 (0.71) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1769 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452952-A1 | A PREPARATION OF QUINAZOLINEDIONES AND USE THEREOF | Council of Scientific and Industrial Research, an Indian Registered Body Incorporated under Regn. of Soc. Act (Act XXI of 1860) (IN) | 2024-10-30 | — | — | EP | claimed |
| CN-118812567-A | Nasopharyngeal carcinoma resisting photosensitizer with photothermal and photodynamic effects and preparation method and application thereof | 湘南学院 | 2024-10-22 | — | — | CN | claimed |
| CN-118717774-A | Preparation method of small molecular compound GI-Y3 and application of small molecular compound GI-Y3 in preparation of anti-cell apoptosis drugs and inhibitors | 温州医科大学附属第一医院 | 2024-10-01 | — | — | CN | claimed |
| CN-118420595-A | STING agonist ST-76 and synthetic method and application thereof | 河南牧业经济学院 | 2024-08-02 | — | — | CN | claimed |
| CN-117777098-A | 4-aminoindazole double-target inhibitor and preparation method and application thereof | 成都市第三人民医院 | 2024-03-29 | — | — | CN | claimed |
| CN-114920704-B | Phenyl piperazine quinazoline compound or pharmaceutically acceptable salt thereof, preparation method and application | 暨南大学 | 2023-11-03 | — | — | CN | claimed |
| WO-2023119320-A1 | A PREPARATION OF QUINAZOLINEDIONES AND USE THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN. OF SOC. ACT (ACT XXI OF 1860) (IN) | 2023-06-29 | — | — | WO | claimed |
| CN-114920704-A | Phenyl piperazine quinazoline compound or pharmaceutically acceptable salt thereof, preparation method and application | 暨南大学 | 2022-08-19 | — | — | CN | claimed |
| EP-3609875-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF N-(3-ETHYNYLPHENYL)-7-METHOXY-6-(3-MORPHOLINOPROPOXY) QUINAZOLIN -4-AMINE DIHYDROCHLORIDE | NATCO PHARMA LTD (IN) | 2021-10-20 | — | — | EP | claimed |
| US-11091470-B2 | Process for the preparation of N-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine dihydrochloride | NATCO PHARMA LIMITED (IN) | 2021-08-17 | — | — | US | claimed |
| CN-102675246-B | Preparation method of pramoxine hydrochloride | JINAN CHENGHUI SHUANGDA CHEMICAL CO LTD | 2014-04-23 | — | — | CN | claimed |
| CN-103524433-A | Method for synthesizing gefitinib and intermediate thereof | TIANJIN PHARMACN MEDICAL TECHNOLOGY CO LTD | 2014-01-22 | — | — | CN | claimed |
| CN-103304491-A | Preparation method of gefitinib | LIANYUNGANG SHENGHE BIOTECHNOLOGY CO LTD | 2013-09-18 | — | — | CN | claimed |
| CN-103012290-A | Preparation method of high-purity gefitinib | QILU PHARMACEUTICAL CO LTD | 2013-04-03 | — | — | CN | claimed |
| CN-101148439-B | Preparing method for gefitinib | UNIV SOUTHEAST | 2011-06-22 | — | — | CN | claimed |
| CN-102030716-A | Method for preparing gefitinib | UNIV SUN YAT SEN | 2011-04-27 | — | — | CN | claimed |
| CN-101205214-B | Benzimidazole compound for anti-inflammatory and analgesic | UNIV SHENYANG | 2011-02-16 | — | — | CN | claimed |
| CN-101570516-B | Method for preparing 4-(3-chlorine-4-fluorophenylalanine)-7-methoxy-6-[3-(4-morpholinyl) propoxy] quinazoline | CHONGQING WORLD HAORUI PHARM CHEM CO LTD | 2011-01-05 | — | — | CN | claimed |
| CN-101570516-A | Method for preparing 4-(3-chlorine-4-fluorophenylalanine)-7-methoxy-6-[3-(4-morpholinyl) propoxy] quinazoline | CHONGQING WORLD HAORUI PHARM C (CN) | 2009-11-04 | — | — | CN | claimed |
| CN-101148439-A | Preparing method for gefitinib | UNIV SOUTHEAST (CN) | 2008-03-26 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091470-B2 | Process for the preparation of N-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine dihydrochloride | MAP7, NQO2, ABL1 | KEAP1 119/4885SMN1; SMN2 915/4885HPGD 1016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.