Hydrochloric Acid

Hydrochloric Acid

SCHEMBL10978

Cl.ClCCCN1CCOCC1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA known ✓ P06280 1/20 0.47
HRH3 known ✓ Q9Y5N1 3/20 0.46
SIGMAR1 known ✓ Q99720 2/20 0.46
CHRM2 known ✓ P08172 1/20 0.46
CHRM1 known ✓ P11229 1/20 0.46
HTR2A known ✓ P28223 1/20 0.46
SCN1A known ✓ P35498 1/20 0.46
HTR2B known ✓ P41595 1/20 0.46
KCNH2 known ✓ Q12809 1/20 0.46
SCN2A known ✓ Q99250 1/20 0.46
SCN3A known ✓ Q9NY46 1/20 0.46
KEAP1 Q14145 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
MAPK1 P28482 2/20 0.49
LMNA P02545 2/20 0.49
USP2 O75604 1/20 0.49
HPGD P15428 1/20 0.47
DUSP3 P51452 1/20 0.47
KDM4E B2RXH2 3/20 0.46
ALDH1A1 P00352 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26621753 0.98 KEAP1 (0.60) KEAP1SMN1; SMN2MAPK1LMNAUSP2
SCHEMBL11065 0.98 KEAP1 (0.60) KEAP1SMN1; SMN2MAPK1LMNAUSP2
Hydrochloric Acid SCHEMBL23116183 0.93 KEAP1 (0.56) KEAP1SMN1; SMN2MAPK1LMNAUSP2
SCHEMBL2746864 0.91 KEAP1 (0.58) KEAP1SMN1; SMN2MAPK1LMNAUSP2
SCHEMBL11536090 0.88 SMN1; SMN2 (0.56) KEAP1SMN1; SMN2MAPK1LMNAUSP2
Hydrochloric Acid SCHEMBL9703482 0.85 ALDH1A1 (0.50) KEAP1SMN1; SMN2MAPK1LMNAUSP2
Hydrochloric Acid SCHEMBL11275 0.85 ALDH1A1 (0.50) KEAP1SMN1; SMN2MAPK1LMNAUSP2
Bicarbonate SCHEMBL28180070 0.84 LMNA (0.49) KEAP1SMN1; SMN2MAPK1LMNAHPGD
Hydrochloric Acid SCHEMBL28756894 0.83 GLA (0.48) KEAP1SMN1; SMN2MAPK1LMNAUSP2
SCHEMBL8997786 0.82 KEAP1 (0.46) KEAP1SMN1; SMN2MAPK1LMNAUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 332 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120157674-A New preparation method of domperidone 刘辉 2025-06-17 CN claimed
EP-2409704-A2 c-Met modulators and methods of use Exelixis Inc. (US) 2012-01-25 EP claimed
CN-101402610-A Synthesis method of 4-(3-chlorine-4-fluorobenzene amino)-7-methoxy-6-[3-(4-morpholinyl)-propoxy] quinoline ZHEJIANG EXCEL PHARMACEUTICAL (CN) 2009-04-08 CN claimed
EP-4673439-A1 STING AGONISTS CONTAINING HYDRAZIDE, HYDRAZINE, AND HYDROXAMIC ACID FUNCTIONAL GROUPS BioNTech SE (DE) 2026-01-07 EP disclosed
EP-4673445-A1 STING AGONISTS CONTAINING BENZYLIC ALCOHOL AND BENZYLIC AMINE FUNCTIONAL GROUPS BioNTech SE (DE) 2026-01-07 EP disclosed
CN-120157674-A New preparation method of domperidone 刘辉 2025-06-17 CN disclosed
CN-120157674-A New preparation method of domperidone 刘辉 2025-06-17 CN disclosed
US-12297190-B2 Modulators of STING (stimulator of interferon genes) PFIZER INC. (US) 2025-05-13 US disclosed
CN-119431355-A Phenyl thiazole derivative, composition and application thereof 徐州医科大学 2025-02-14 CN disclosed
US-20250011319-A1 SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF LOMOND THERAPEUTICS, INC. 2025-01-09 US disclosed
US-12091425-B2 Compounds that inhibit MCL-1 protein AMGEN INC. (US) 2024-09-17 US disclosed
US-4518603-A ANTIDEPRESSANTS A. H. ROBINS COMPANY, INC. (US) 1985-05-21 US disclosed
US-4495183-A ANTIULCER AGENTS- GASTROLINTESTINAL DISORDERS A. H. ROBINS COMPANY, INCORPORATED (US) 1985-01-22 US disclosed
US-4480100-A CHEMICAL INTERMEDIATES FOR ANTIDEPRESSANTS A. H. ROBINS COMPANY, INC. (US) 1984-10-30 US disclosed
US-4447361-A ANTIDEPRESSANT A. H. ROBINS COMPANY, INC. (US) 1984-05-08 US disclosed
EP-0107261-A2 (2-((Nitropyridinyl)amino)phenyl)arylmethanones and salts, their use in medicine, pharmaceutical compositions containing them and their use in the preparation of (2-((aminopyridinyl)amino)phenyl)arylmethanones and pyrido(1,4)benzodiazepines A.H. ROBINS COMPANY, INCORPORATED (US) 1984-05-02 EP disclosed
EP-0099614-A2 Nitro, amino and aroylamino-N-phenylpyridinamines and their use in a process for preparing pyrido(1,4)benzodiazapines A.H. ROBINS COMPANY, INCORPORATED (US) 1984-02-01 EP disclosed
EP-0076017-A2 Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor A.H. ROBINS COMPANY, INCORPORATED (US) 1983-04-06 EP disclosed
US-4230850-A HYPOTENSIVE AGENTS, VASODILATION LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1980-10-28 US disclosed
US-4094870-A 2-Substituted thio-1,4-benzodiazepine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1978-06-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12297190-B2 Modulators of STING (stimulator of interferon genes) STING1, IRF3, CGAS GLA 1538/4885HRH3 2049/4885SIGMAR1 2484/4885
US-20250011319-A1 SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF FLT3, PDXK, PHKG1 GLA 4296/4885HRH3 305/4885SIGMAR1 3637/4885
US-12091425-B2 Compounds that inhibit MCL-1 protein MCL1, BCL9, BCL2L1 GLA 2956/4885HRH3 4640/4885SIGMAR1 4041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.