Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11073422 | 0.82 | SLC6A3 (0.40) | MAPTSLC6A3SLC6A2SLC6A4NPC1 | |
| SCHEMBL6001756 | 0.79 | SLC6A3 (0.41) | TAAR1SLC6A3IDO1NPC1RAB9A | |
| SCHEMBL30839554 | 0.76 | KDM4C (0.40) | MAPTSLC6A3KDM4ETSHRMETAP2 | |
| SCHEMBL28551226 | 0.72 | L3MBTL1 (0.50) | MAPTTAAR1IDO1SMN1; SMN2TDP1 | |
| SCHEMBL2093828 | 0.71 | SCN9A (0.47) | SLC6A3SLC6A2SLC6A4CYP2D6TDP1 | |
| SCHEMBL6286238 | 0.71 | SLC6A3 (0.38) | MAPTNPSR1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8703610 | 0.71 | TAAR1 (0.64) | TAAR1IDO1CYP1A2CYP2D6TSHR | |
| SCHEMBL29930048 | 0.71 | TAAR1 (0.64) | TAAR1IDO1CYP1A2CYP2D6TSHR | |
| SCHEMBL6287745 | 0.70 | CYP1A2 (0.41) | SLC6A3NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL2793555 | 0.69 | GPR84 (0.59) | MAPTTAAR1RAB9AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4479952-A | 1-(4-benzyl-2-thiazolyl) piperazine; antiinflammatory; immunomodulator | SCIENCE UNION ET CIE (FR) | 1984-10-30 | — | — | US | disclosed |